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Specifically, compared with corresponding adult counterparts who initiated before age 18 (Table 5), the number of moderate-severe SUDs was 32% lower for those initiating alcohol at ages 2129 (IDR = 0.68, 95% CI = 0.570.83), 21% lower among those initiating cannabis at ages 2129 (IDR = 0.79, 95% CI = 0.690.90), 2336% lower (IDR range=0.640.77, 95% CIs=0.540.93) among those who never initiated hallucinogen, heroin, cocaine, inhalants, or methamphetamine, and 4562% lower (IDR range=0.380.55, 95% CIs=0.310.76) among those who never initiated alcohol, cannabis, or tobacco/nicotine use

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Nicotine is indeed a vasoconstrictor, meaning it tightens blood vessels and raises blood pressure